Isnin, 7 Oktober 2013

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US stocks ease as budget fight continues

Posted: 07 Oct 2013 04:29 PM PDT

NEW YORK: US stocks on Monday finished lower as a partial US government shutdown entered its second week with no sign of resolution.

The Dow Jones Industrial Average fell 136.34 points (0.90 percent) to 14,936.24. The broad-based S&P 500 tumbled 14.38 points (0.85 percent) to 1,676.12, while the tech-rich Nasdaq Composite Index gave up 37.38 points (0.98 percent) at 3,770.38.

The paralysis in Washington continued to weigh on markets. Analysts have expressed particular concern that the fight over the budget will stymie efforts to raise the budget ceiling, resulting in a US default with damaging economic consequences.

However, the market still considers a US default unlikely, said Peter Cardillo, chief market economist at Rockwell Global Capital.

"If the markets were really fearful of a default.... we wouldn't be down a half a percent or three-quarters of a percent," Cardillo said. "We would be down a heck of a lot more."

Banking equities were among the hardest-hit. Dow component JPMorgan Chase fell 1.6 percent, Citigroup dropped 2.0 percent and Wells Fargo dipped 1.7 percent.

Dow component Boeing dropped 0.4 percent after Japan Airlines announced a massive US$9.5 billion aircraft order with competitor Airbus. The decision challenged Boeing's dominance in the Japanese market.

Dow component IBM took a 1.1 percent hit after Barclays downgraded the stock to "equal weight" due to the lack of near-term catalysts for the stock.

Other technology companies also suffered, including Microsoft (down 1.7 percent), Amazon (down 2.8 percent), Priceline (down 1.9 percent) and eBay (down 1.8 percent).

An exception was Apple, which advanced 1.0 percent after Jefferies upgraded the stock to "buy" following meetings with Asian suppliers who were enthusiastic about upcoming Apple products.-- AFP

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US Congress enters crucial week in budget, debt limit battles - Reuters

Posted: 07 Oct 2013 08:03 AM PDT

U.S. House Speaker John Boehner (R-OH) arrives at the U.S. Capitol in Washington, October 5, 2013. REUTERS/Jonathan Ernst

WASHINGTON | Mon Oct 7, 2013 11:00am EDT

(Reuters) - As the U.S. government moved into the second week of a shutdown on Monday with no end in sight, a deadlocked U.S. Congress also confronted an October 17 deadline to increase the nation's borrowing power or risk default.

Republican House of Representatives Speaker John Boehner vowed not to raise the U.S. debt ceiling without a "serious conversation" about what is driving the debt, while Democrats said it was irresponsible and reckless to raise the possibility of a U.S. default.

The last big confrontation over the debt ceiling, in August 2011, ended with an 11th-hour agreement under pressure from shaken markets and warnings of an economic catastrophe if there was a default.

A similar last-minute resolution remains a distinct possibility this time.

Equities investors were unnerved by the apparent hardening of stances over the weekend. U.S. stocks opened sharply lower on Monday and European shares fell to a four-month low.

In comments on Sunday television political talk shows, neither Republicans nor Democrats offered any sign of impending agreement on either the shutdown or the debt ceiling, and both blamed the other side for the impasse.

"I'm willing to sit down and have a conversation with the president," said Boehner, speaking on ABC's "This Week." But, he added, President Barack Obama's "refusal to negotiate is putting our country at risk."

On CNN's "State of the Union" program, Treasury Secretary Jack Lew said: "Congress is playing with fire," adding that Obama would not negotiate until "Congress does its job" by reopening the government and raising the debt ceiling.

China, the biggest foreign holder of U.S. Treasuries, urged Washington to take decisive steps to avoid a crisis and ensure the safety of Chinese investments.

"The United States is totally clear about China's concerns about the fiscal cliff," Vice Finance Minister Zhu Guangyao said in the Chinese government's first public comment on the October 17 deadline.

"We hope the United States fully understands the lessons of history," Zhu told reporters in Beijing, referring to the downgrade of the U.S. credit rating by Standard & Poor's in 2011.

China held $1.277 trillion of U.S. Treasuries as of last July, according to U.S. Treasury data released month.

"Who should be worrying most of a possible U.S. default?" asked Deutsche Bank analysts. "Looking at the top holders of U.S. Treasuries, recipients of U.S. social security should be most concerned, followed by the Fed and then China."

Democratic Senator Charles Schumer, whose constituency includes Wall Street and New York's financial hub, said Boehner would be forced to act as the deadline for the nation's debt ceiling gets closer, calling it "too dangerous" to not raise the U.S. debt limit and saying any default could lead to an economic "recession, depression or worse."

"The economy could collapse. Will it? No one's certain, but there's a high enough chance that no one - no one - should risk it," Schumer told CNN's "New Day."

SHUTDOWN, DEBT CEILING ISSUES MERGED

The two issues of the Federal government shutdown and the debt ceiling started out separately in the House but have been merged by the pressure of time.

Conservative Republicans in the House have resisted funding the government for the current fiscal year until they extract concessions from Obama that would delay or defund his signature healthcare law, which launched October 1.

Many of the conservatives want a similar condition placed on raising the debt ceiling, but in his list of debt-ceiling demands Sunday, Boehner did not mention the Affordable Care Act, commonly known as Obamacare.

"It's time to talk about the spending problem," said Boehner, including measures to rein in costs of entitlement programs such as the Social Security retirement system and Medicare, the government-run health insurance program for seniors.

Harry Reid, leader of the Democratic-led Senate, is expected to decide soon on whether to try to open formal debate on a "clean" bill, without extraneous issues attached, to raise the U.S. Treasury's borrowing authority.

Passage of such a measure would require at least six of the Senate's 46 Republicans to join its 54 Democrats in order to overcome potential procedural hurdles that opponents of Obamacare could erect.

According to one Senate Democratic aide, the debt limit hike might be coupled with a new initiative to reform the U.S. tax code and achieve long-term savings in Social Security and Medicare, whose expenses have soared along with the population of retirees.

Republican lawmakers have floated other ideas, such as a very short debt limit increase, which would create time for more negotiations at the expense of further market uncertainty, and repeal of a medical device tax.

The tax is expected to generate some $30 billion over 10 years to help pay for healthcare insurance subsidies under Obamacare.

Some Democrats favor repealing the tax, but they insist that replacement revenues be found and repeal be considered only after the government reopens and the debt limit is raised.

MAJOR PROBLEMS IN HOUSE

Agreement in the Senate would send the tangle of issues back into the House, where the Republican caucus has adopted a hard line on both Obamacare and the debt ceiling.

There may be enough votes in the House to pass a clean bill, according to some analysts. That would require almost all of the House's 200 Democrats and about 20 of its 232 Republicans to vote in favor. But taking such a vote would require Boehner to violate his policy against bringing a vote on any legislation favored by less than a majority of House Republicans.

Reid spokesman Adam Jentleson issued a statement on Monday attacking what he called "Boehner's credibility problem," including the speaker's assertion that there are not enough votes in the House to pass a clean bill.

"There is now a consistent pattern of Speaker Boehner saying things that fly in the face of the facts or stand at odds with his past actions," Jentleson said. "Americans across the country are suffering because Speaker Boehner refuses to come to grips with reality."

For the moment, neither side is moving toward accommodation, and the stakes rise with the passage of time.

For any deal to work, negotiators probably would have to choreograph a multipronged approach that allows all sides to declare victory, even if it is one that sets up another battle in mid-November or December.

White House officials were firm on Monday that Obama will not negotiate under the threat of a default and repeated that it is up to Congress to raise the U.S. borrowing cap.

While the shutdown itself is unlikely to cause major disruption in the markets, a fight over the debt ceiling could. From July 31 thru August 2 during the debt-limit standoff in 2011, the S&P 500 index lost 3 percent, and the deadlock led to a downgrade of the U.S. credit rating to AA-plus from AAA by S&P.

The outlooks from Moody's and S&P, the only agency so far to have lowered its rating on U.S. debt, are both at "stable," but Fitch Ratings has indicated a negative outlook for the U.S. debt rating.

All three agencies have said the U.S. debt profile has improved substantially over the past two years, with gross domestic product growth, while slow, proving to be persistently positive and the budget deficit trending lower.

Fitch said in a note last week that the U.S. rating is at risk in the current showdown over the debt ceiling because failure to raise it sufficiently in advance of the deadline raises questions about the full faith and credit of the United States to honor its obligations.

Political gridlock remains the greatest risk to the U.S. outlook, Fitch said in the note on October 1, the first day of the partial government shutdown.

"This 'faith' is a key underpinning of the U.S. dollar's global reserve currency status and reason why the US 'AAA' rating can tolerate a substantially higher level of public debt than other 'AAA' sovereigns," Fitch said.

(The story has been filed again to correct that China is the biggest foreign holder of U.S. debt in paragraph nine. The error also appeared in previous updates.)

(Additional reporting by Susan Heavey, Thomas Ferraro, Dan Burns, Ben Blanchard in Beijing and Walker Simon in New York; Editing by Fred Barbash, Claudia Parsons, Vicki Allen and Bill Trott)

Vesicle traffic' research wins Nobel Prize - CBC.ca

Posted: 07 Oct 2013 08:06 AM PDT

Two Americans and a German-American won the Nobel Prize in medicine on Monday for discovering how key substances are transported within cells, a process involved in such important activities as brain cell communication and the release of insulin.

James Rothman, 62, of Yale University, Randy Schekman, 64, of the University of California, Berkeley, and Dr. Thomas Sudhof, 57, of Stanford University shared the $1.2 million US prize for their research on how tiny bubbles called vesicles act as cargo carriers inside cells.

This traffic control system ensures that the cargo is delivered to the right place at the right time and keeps activities inside cells from descending into chaos, the committee said. Defects can be harmful, leading to neurological diseases, diabetes and disorders affecting the immune system.

At a glance

WHO WON?: Americans James E. Rothman, professor of biomedical sciences at Yale University; Randy W. Schekman, professor of cell and developmental biology at the University of California, Berkeley; and German-born Thomas C. Suedhof, professor in the School of Medicine at Stanford University. 

FOR WHAT?: For their discoveries of how hormones, enzymes and other key materials are transported within cells, a process known as "vesicle traffic."

SIGNIFICANCE: The discovery solves the mystery of how animal cells organize their internal transportation system to direct molecules to the correct place. This helps explain how certain illnesses, including diabetes, tetanus and many immune diseases, work. 

"Imagine hundreds of thousands of people who are travelling around hundreds of miles of streets; how are they going to find the right way? Where will the bus stop and open its doors so that people can get out?" Nobel committee secretary Goran Hansson said. "There are similar problems in the cell."

The winners' discoveries in the 1970s, `80s and `90s have helped doctors diagnose a severe form of epilepsy and immune deficiency diseases in children, Hansson said. In the future, scientists hope the research could lead to medicines against more common types of epilepsy, diabetes and other metabolism deficiencies, he added.

Schekman said he was awakened at 1 a.m. at his home in California by the chairman of the prize committee, just as he was suffering from jetlag after returning from a trip to Germany the night before.

"I wasn't thinking too straight. I didn't have anything elegant to say," he told The Associated Press. "All I could say was 'Oh my God,' and that was that."

He called the prize a wonderful acknowledgement of the work he and his students had done and said he knew it would change his life.

"I called my lab manager and I told him to go buy a couple bottles of Champagne and expect to have a celebration with my lab," he said.

'This is not an overnight thing'

In the 1970s, Schekman discovered a set of genes that were required for vesicle transport, while Rothman revealed in the 1980s and 1990s how vesicles delivered their cargo to the right places. Also in the '90s, Sudhof identified the machinery that controls when vesicles release chemical messengers from one brain cell that let it communicate with another.

"This is not an overnight thing. Most of it has been accomplished and developed over many years, if not decades," Rothman told the AP.

Nobel Medicine

Thomas Suedhof is one of three people to win the 2013 Nobel Prize in medicine. (The Associated Press)

Rothman said he lost grant money for the work recognized by the Nobel committee, but he will now reapply, hoping the Nobel prize will make a difference in receiving funding.

Sudhof, who was born in Germany but moved to the U.S. in 1983 and also has U.S. citizenship, told the AP he received the call from the committee while driving toward the city of Baeza, in southern Spain, where he was due to give a talk.

"I got the call while I was driving and like a good citizen I pulled over and picked up the phone," he said. "To be honest, I thought at first it was a joke. I have a lot of friends who might play these kinds of tricks."

The medicine prize kicked off this year's Nobel announcements. The awards in physics, chemistry, literature, peace and economics will be announced by other prize juries this week and next. Each prize is worth 8 million Swedish kronor ($1.2 million).

'Fundamental' research

Rothman and Schekman won the Albert Lasker Basic Medical Research Award for their research in 2002 — an award often seen as a precursor of a Nobel Prize. Sudhof won the Lasker award this year.

"I might have been just as happy to have been a practicing primary-care doctor," Sudhof said after winning that prize. "But as a medical student I had interacted with patients suffering from neurodegeneration or acute clinical schizophrenia. It left an indelible mark on my memory."

Other prizes

The panel that selects the winner of the Nobel Prize for literature says it will announce its decision on Thursday. That means the dates of all the 2013 Nobel Prize announcements have been set. The physics prize will be announced on Tuesday and chemistry on Wednesday. The Nobel Peace Prize will be announced on Friday, and the economics award is set for Oct. 14.

Jeremy Berg, former director of the National Institute of General Medical Sciences in Bethesda, Maryland, said Monday's announcement was "long overdue" and widely expected because the research was "so fundamental, and has driven so much other research."

Berg, who now directs the Institute for Personalized Medicine at the University of Pittsburgh, said the work provided the intellectual framework that scientists use to study how brain cells communicate and how other cells release hormones. In both cases, vesicles play a key role by delivering their cargo to the cell surface and releasing it to the outside, he told the AP.

So the work has indirectly affected research into virtually all neurological disease as well as other diseases, he said.

Established by Swedish industrialist Alfred Nobel, the Nobel Prizes have been handed out by award committees in Stockholm and Oslo since 1901. The winners always receive their awards on Dec. 10, the anniversary of Nobel's death in 1896.

Last year's Nobel medicine award went to Britain's John Gurdon and Japan's Shinya Yamanaka for their contributions to stem cell science.

Kredit: www.nst.com.my
 

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